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University Medical Center of Utrecht and Philips Start Pilot Study for New Treatment of Breast Cancer

Mon, 8 Oct 2012 09:50:29 EST

First patient in pilot study treated using dedicated MR-guided High Intensity Focused Ultrasound (MR-HIFU) system

Utrecht, The Netherlands – The University Medical Center Utrecht (Utrecht, The Netherlands) and Royal Philips Electronics (NYSE:PHG, AEX:PHIA) today announced that they have started a pilot clinical study to evaluate a new treatment for breast cancer based on a technology called MR-guided High Intensity Focused Ultrasound (MR-HIFU). To facilitate this study, Philips has built a dedicated investigational system optimized for the anatomy of the female breast. The first patient in the study has already been treated using the system.

MR-HIFU has emerged as a technology with the potential to non-invasively destroy tumors by heating them up while they are still inside the body. As its name suggests, high intensity focused ultrasound directs sound energy into a tumor. This sound energy then dissipates in the tumor generating heat. The technique is capable of achieving tissue temperatures in excess of 65 degrees Celsius, high enough to kill tumor cells without damaging the surrounding tissue. Magnetic Resonance (MR) imaging provides real-time imaging of soft tissue structures so that the HIFU beam can be accurately focused onto the tumor. It also spatially maps local tissue temperatures in order to provide real-time feedback for controlling the applied temperature profiles.

To perform the study, UMC Utrecht is working closely with the Diakonessenhuis Hospital (Utrecht, The Netherlands), from which patients are being enrolled. The MR-HIFU treatment is being carried out under local anesthetic or sedation. Following this treatment, a conventional surgical procedure will be performed to verify the precision of the treatment. The initial aim of the study is to assess the image quality achieved by the MR-HIFU system as well as the safety and precision of the technique in this particular application.

'This new pilot study targets patients with small breast tumors that have not metastasized; these patients belong to a group that encompasses approximately a quarter of all breast cancer patients in the Netherlands,' says Maurice van den Bosch, MD, interventional radiologist and research leader at the University Medical Center Utrecht. 'An important aspect of the MR-HIFU technique is that the skin stays completely intact, since everything can be done non-invasively: operating without making any incisions.'

'MR-guided HIFU could become a very powerful tool in the hands of physicians,' says Falko Busse, General Manager MR-Therapy at Philips Healthcare. 'The benefits of its non-invasiveness have already been shown in the treatment of benign tumors of the uterus, offering patients an outpatient procedure with faster recovery and lower complication rates than surgical removal. We are now further developing this technology with the ultimate goal to advance cancer care.'

This pilot study into MR-HIFU treatment combines the clinical expertise and medical technology know-how of UMC Utrecht and Philips respectively. The study is part of a larger Dutch research program with a total budget of EUR 11 million. The Center for Translational Molecular Medicine (CTMM) - a public-private partnership for Netherlands-based translational research - is the main funder of the program. Philips and the Netherlands Organization for Health Research and Development (ZonMw) are also contributors.


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About Royal Philips Electronics

Royal Philips Electronics (NYSE: PHG, AEX: PHI) is a diversified health and well-being company, focused on improving people's lives through meaningful innovation in the areas of Healthcare, Consumer Lifestyle and Lighting. Headquartered in the Netherlands, Philips posted 2011 sales of EUR 22.6 billion and employs approximately 122,000 employees with sales and services in more than 100 countries. The company is a leader in cardiac care, acute care and home healthcare, energy efficient lighting solutions and new lighting applications, as well as male shaving and grooming, home and portable entertainment and oral healthcare. News from Philips is located at www.philips.com/newscenter.

About the University Medical Center Utrecht (UMC Utrecht)

The University Medical Center Utrecht is one of the largest public healthcare institutions in the Netherlands. With almost 11,000 employees, it is constantly building on the provision of good healthcare services based on knowledge and people. The UMC Utrecht strives to be a leading international university medical center where knowledge about health, disease and healthcare is generated, tested, shared and applied. UMC Utrecht forms part of the Netherlands Federation of University Medical Centers ('Nederlandse Federatie van Universitair Medische Centra, NFU'). The NFU is a partnership that brings together the eight university medical centers (UMCs) in the Netherlands. Visit the site for more information about the NFU. More news about the UMC Utrecht can be found at: http://www.umcutrecht.nl/zorg/nieuws/


Source: WebWire



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